• Evidence of a variant induction of apoptosis

  2019-05-15

  

  Evidence of a variant induction of apoptosis to vorinostat in different DLBCL cell lines according to HAT mutational status implies that defects in CREBBP/EP300 could potentially explain the heterogeneous observations in clinical trials of vorinostat in NHL. These findings, however, need to be confi

• Upon diagnosis the patient s lymphoma and HLH

  2019-05-15

  

  Upon diagnosis, the patient׳s lymphoma and HLH represented a therapeutic dilemma. Effective early therapy reduces mortality of HLH from 95% to 30–35% [4]. The HLH-2004 treatment protocol consists of T-cell targeted immunosupression with dexamethasone and cyclosporine, macrophage targeted etoposide w

• Analyses such as those used by Burke and

  2019-05-15

  

  Analyses such as those used by Burke and colleagues rely on periodic cross-sectional surveys that are not linked to available or civic registration and vital statistics databases. These surveys are also limited by the inevitable time lag between analyses and feedback to health systems and policy mak

• Preventive chemotherapy for schistosomiasis is

  2019-05-15

  

  Preventive chemotherapy for schistosomiasis is rapidly scaling up worldwide. The global coverage that was less than 10% in 2010 is now higher than 30%, however, the main limitation for the scaling up is the availability of donated drug. In school age children, the age group for which praziquantel is

• br As one of the

  2019-05-15

  

  As one of the few countries that have achieved Millennium Development Goals 4 and 5, China has had a remarkable decline in under-5 mortality rate in past three decades. Drivers of such rapid improvement in China have been widely discussed. In , Chunhua He and colleagues report a decline in under-

• br Acknowledgments This work was supported by grants

  2019-05-15

  

  Acknowledgments This work was supported by grants from the National Science Council (project number: MOST-103-2320-B-040-004 and NSC 102-2313-B-002 -039 -MY3). The authors would like to thank Dr. Bernard A. Schwetz for carefully reading the manuscript and helpful discussions which improved the a

• Our group then carried out a

  2019-05-15

  

  Our group then carried out a study to determine the substrate sites and arrhythmogenic mechanisms of the BrS [29]. We found that all our BrS patients had abnormal low voltage, fractionated late potentials exclusively clustering in the anterior aspect of the RVOT epicardium and not seen anywhere else

• br Discussion In this case

  2019-05-15

  

  Discussion In this case report, we demonstrated the consistent fusion of P-waves during CS os pacing, except for the last captured beat, which was entrained but not fused, thereby satisfying the entrainment criteria [2,3]. The tachycardia could be induced with reproducible results by a single atr

• br Introduction The early repolarization

  2019-05-15

  

  Introduction The early repolarization (ER) pattern has been considered a benign electrocardiographic phenomenon affecting 2–5% of the general population and is most commonly seen in healthy young men and athletes [1–3]. Recent studies have challenged the view of this electrocardiogram (ECG) varia

• Given the recognized effects of bisphosphonates in metastati

  2019-05-15

  

  Given the recognized effects of bisphosphonates in metastatic breast cancer [14,15] and that potential anticancer effects have been demonstrated in preclinical [16], translational [17], patients with cancer therapy-induced bone loss [18] and Yeast Extract based-studies [19,20] a number of clinical t

• Introduction Schwannoma is a benign tumor of neuroectodermal

  2019-05-15

  

  Introduction Schwannoma is a benign tumor of neuroectodermal derivation that originates from Schwann PS-341 which cover the peripheral nerves [3]. Approximately 25–40% of all schwannomas occur in the head and neck. These tumors most commonly arise in the soft tissues of the head and neck and on th

• br Discussion This study shows

  2019-05-15

  

  Discussion This study shows that the risk of all-cause mortality in patients with atrial fibrillation is directly associated with RDW in a dose-response manner. This association was independent of known risk factors of mortality. Notably, RDW is associated with all-cause mortality regardless of a

• Visto el franquismo como el gran eje de la discordia

  2019-05-14

  

  Visto el franquismo como el gran eje de la discordia, el punto de in flexión se produjo en 1949 con motivo de la presentación en la onu de una propuesta conjunta de cuatro países de América Latina: Brasil, Bolivia, Colombia y Perú. La propuesta de resolución del cuatripartito latinoamericano (proyec

• As shown in Fig out of the patients who

  2019-05-14

  

  As shown in Fig. 2, 40 out of the 60 patients (66.6%) who developed amiodarone-induced hypothyroidism, and 10 out of the 30 patients (33.3%) who developed amiodarone-induced hyperthyroidism, were diagnosed within two years of reverse transcriptase inhibitors of amiodarone therapy. Amiodarone-induce

• br Methods br Results A total

  2019-05-13

  

  Methods Results A total of 2136 cases, including 614 controls, and 707 LAA, 375 SVO, and 440 HICH cases, were enrolled in this study. Clinical parameters between the control individuals and patients with different stroke subtypes are listed in Table 1. The average age and serum HDL-C level wer

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