• Acute and transient MF activation is part

  2018-11-08

  

  Acute and transient MF activation is part of the body’s normal wound healing program, but persistent MFs contribute to fibrosis by excessively producing and contracting collagenous extracellular matrix (ECM) into stiff scar tissue (Hinz et al., 2012). In turn, the stiffness of mature scar promotes m

• In this study we examined the

  2018-11-08

  

  In this study, we examined the impact of hormonal signaling on SSC self-renewal using follicle-stimulating hormone β (Fshb; FSH β subunit) and luteinizing hormone/choriogonadotropin receptor (Lhcgr) KO mice. FSH acts on Sertoli cyclin dependent kinase within seminiferous tubules, while LHCGR are de

• PD 0332991 br Experimental Procedures br Author Contribution

  2018-11-07

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Tissue engineering technology has become one of the most promising therapeutic approaches for bone regeneration in bone defects (Zou et al., 2011; Ye et al., 2011; Xiao et al., 2011). As a source of mesenchymal ste

• Practical considerations limit the use of

  2018-11-07

  

  Practical considerations limit the use of autologous NSCs for cell-based therapy. Allogeneic donor cells remain an attractive possibility if an appropriate source can be identified. Although the self-renewing NSCs present in developing TAK-875 tissue could be used as a renewable cell population, cu

• In in vivo animal models

  2018-11-07

  

  In in vivo animal models, we observed no rejection signs in the iPS-RPE allografts of MHC-matched monkeys (DrpZ1 and DrpZ17); for example, fundus photographs revealed no exudation, FA showed no vascular leakage of fluorescein, and OCT indicated there was no retinal edema around the transplanted RPE

• There were countries for which we had iAD data

  2018-11-07

  

  There were 58 countries for which we had iAD data and for which the UN database provided information about the rate of adult literacy. When these variables were simply correlated (see the Appendix for a table of simple correlations among all the measures mentioned in Methods section), a significant

• In total compositional data of

  2018-11-07

  

  In total 18 compositional data of Rw have been collected from the high-P experiments with some bulk compositions broadly appropriate for the upper gadobutrol such as the depleted harzburgite with 82 wt% olivine removal (Irifune and Ringwood, 1987), pyrolite (Irifune, 1994), Tinaquillo lherzolite (W

• br Metodolog a multidimensional de M

  2018-11-07

  

  5. Metodología multidimensional de México El indicador para la dimensión del bienestar es el ingreso corriente per cápita. Las personas carentes se definen con el método de pobreza de ingresos. En el espacio de los derechos sociales se consideran seis indicadores dicotómicos. Siendo éstos el reza

• Today recent technological advances have dramatically improv

  2018-11-07

  

  Today, recent technological advances have dramatically improved the prospect of applying broadly the concept of precision medicine. Large-scale databases, omics technologies, cellular assays, epigenetics, informatics as well as imaging technologies converge towards optimum disease prevention, diagno

• br Results br Conclusions The

  2018-11-07

  

  Results Conclusions The MR analysis is a recent improvement in genetic epidemiology (Jansen et al., 2014; Ding et al., 2009; Didelez and Sheehan, 2007). The independent distribution of alleles/genotypes means that the association of a disease with a genetic variation would not be affected by c

• HIV subtype C isolates are less fit than subtype

  2018-11-07

  

  HIV-1 subtype C isolates are less fit than subtype A which are both less fit than subtype B and D HIV-1 isolates, a finding established by over 2000 direct head-to-head dual virus competitions in primary CD4+ T-cells and macrophages from HIV-negative donors of different races/ethnicities (Abraha et

• Almost any drug is eventually found to

  2018-11-07

  

  Almost any drug is eventually found to have off-target effects, beyond effects anticipated based on knowledge about their presumed targets. To prove that putative senolytic drugs actually cause alleviation of phenotypes through eliminating senescent glucagon receptor in vivo over and above any off-

• Growing concerns about the robustness and reproducibility of

  2018-11-07

  

  Growing concerns about the robustness and reproducibility of neuroimaging results have recently garnered unanimous attention (Abi-Dargham and Horga, 2016; Blackford, 2017; Lerch et al., 2017; Poldrack et al., 2017). The quest for pragmatically usable biomarkers calls for the rigorous assessment of t

• Antigen Rv is a secretory antigen and a virulence factor

  2018-11-07

  

  Antigen Rv0577 is a secretory antigen and a virulence factor associated with the replication of M. tuberculosis. The antigen is an agonist of Toll-like receptor 2 (TLR2) and can promote maturation of dendritic cells (Byun et al., 2012). Rv2875 encodes a cell membrane-associated antigen, MPT70, of M.

• br Semen collection and physiological tests

  2018-11-07

  

  Semen collection and physiological tests Eleven adult males of a standardized genetic origin [2] housed in the INRA PEAT experimental unit (Nouzilly, France) were collected twice a week. Sperm concentrations were determined [3] and individual ejaculates were diluted 1:1 in Beltsville Poultry Seme

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