In the present study we

2018-10-20

In the present study, we generated an Eva1a knockout (KO) mouse to study the physiological role of EVA1A in vivo. The analysis of Eva1a KO embryos and isolated NSCs revealed the function of EVA1A in self-renewal and neuronal differentiation of NSCs. Our study highlighted a previously unknown role of

The establishment of a robust ISC isolation protocol

2018-10-20

The establishment of a robust ISC isolation protocol that does not rely on the use of transgenic reporter URB597 is critical to study ISCs in any transgene-free mouse strain. Therefore, we used our SM6 strategy to isolate cells from wild-type (WT) C57BL/6 animals (Figure S3C) and performed single-

To address this issue we examined

2018-10-20

To address this issue, we examined striatal neurons innervated by nigral DA neurons using the plant lectin wheat-germ agglutinin (WGA). WGA can be efficiently transferred between neurons via synapses and has been already used as a transsynaptic tracer (Fabian and Coulter, 1985; Broadwell and Balin,

However in these models human hematopoietic

2018-10-20

However, in these models, human hematopoietic reconstitution is usually B-lymphoid dominant, and engraftment of human myeloid, erythroid, and megakaryocyte lineages is limited (Doulatov et al., 2012; Ito et al., 2012; Rongvaux et al., 2013; Yamauchi et al., 2013). This skewed reconstitution could be

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2018-07-29