• Tetracyclines constitute one of the most important

  2023-11-27

  

  Tetracyclines constitute one of the most important antibiotic groups used as veterinary and human medicine and as feed additives in the agricultural sector (Li et al., 2011a, Simon, 2005). Annual worldwide production of tetracyclines is estimated to be in the thousands of tons (Michalova et al., 200

• We have recently begun to demonstrate this

  2023-11-27

  

  We have recently begun to demonstrate this concept by reporting a novel class of β-hairpin peptidomimetics, built on a piperidine-pyrrolidine semi-rigid β-turn inducer [12] and bearing two recognition pentapeptide sequences, designed on oligomeric and fibril structures of Aβ1-42 (compound 1, Fig. 1)

• Although AMPK is a negative regulator of bioenergetic

  2023-11-27

  

  Although AMPK is a negative regulator of bioenergetic reprogramming in cancer cells, little is known about the role of AMPK in immunometabolism in sepsis. Our current study indicates that AMPKα dysfunction enhances PKM2-dependent aerobic glycolysis, which results in HMGB1 release in macrophages and

• WKY and SHR strains have important differences

  2023-11-27

  

  WKY and SHR strains have important differences mainly in their sympathetic status but also in the activity of the RAS. The development of hypertension in SHR is clearly related to an increase in sympathetic activity [51], [11]. In addition, increased renal sympathetic nerve activity led to an increa

• Another interesting interaction concerns NMDA preconditionin

  2023-11-27

  

  Another interesting interaction concerns NMDA preconditioning to protect against glutamate neurotoxicity. It has been shown that an A1R antagonist prevented neuroprotection evoked by NMDA preconditioning against glutamate-induced cellular damage in cerebellar granule cells. In this study, the functi

• Sperm total motility and hyperactivated

  2023-11-27

  

  Sperm total motility and hyperactivated motility are mediated by PLD-dependent Cy7 carboxylic acid (non-sulfonated) polymerization [20]. Reduction of PIP2 synthesis inhibited actin polymerization and motility, and increasing PIP2 synthesis enhanced these activities. Furthermore, sperm demonstrating

• The first suggestions that the cleaved intracellular domain

  2023-11-27

  

  The first suggestions that the cleaved intracellular domain of APP, AICD, might transit to the nucleus and hence selectively regulate gene transcription arose from analogies with the Notch receptor signalling system where similar intra-membrane proteolysis occurs [84], [85] and it was later confirme

• br Diabetes and obesity fit or

  2023-11-27

  

  Diabetes and obesity: fit or fat; sugar or not: the autophagic verdict Type 2 diabetes and obesity are among the most emerging health problems worldwide. The factors that are responsible for the establishment of diabetes include decreased pilocarpine hydrochloride mg production, rise in adiposit

• br Material and methods br Results

  2023-11-24

  

  Material and methods Results Discussion Asparagine, arginine, leucine, methionine, and glutamine are the essential KU-0060648 for cancer cells and intensively investigated for the development of selective targeted therapeutics. Among them, asparagine depleting bacterial enzyme asparaginase

• Since the beginning of s more than papers

  2023-11-24

  

  Since the beginning of 1990s, more than 17,000 papers about physiological relevance of antioxidants have been published according to data from web of science. Based on the available literature, it seems that assessing the antioxidant potential of food by means of in vitro assays or solely epidemiol

• Since primitive societies plants herbs

  2023-11-24

  

  Since primitive societies, plants, herbs and seeds, rich in phytochemicals, were used due to their benefits in human health. These molecules were shown to present a diverse array of action mechanisms, including antioxidant activity, enzyme stimulation, hormones mimicking and by interfering with DNA

• br Androgen interference with the action of arachidonic

  2023-11-24

  

  Androgen interference with the action of arachidonic GSK1016790A metabolites’ actions; the other side of the coin Arachidonic acid, being a polyunsaturated fatty acid present in the phospholipids of the membrane of cells, is highly abundant within the organism. It is mainly involved in cellular

• br Conclusions br Conflict of interest br

  2023-11-24

  

  Conclusions Conflict of interest Introduction Plants often encounter a series of abiotic stresses during the growth process, including high salinity, extreme temperatures and drought (Knight and Knight, 2001). Plants can adapt through ionic and osmotic homeostasis or osmotic adjustment, con

• br Colabeling evidence for ACh

  2023-11-24

  

  Colabeling evidence for ACh and GABA cotransmission Though functional demonstrations of ACh/GABA cotransmission remain largely limited to the retina and our recent analyses of cortex (Lee et al., 2010, Saunders et al., 2015a, Saunders et al., 2015b), evidence suggestive of ACh/GABA cotransmission

• Aurora A overexpression is also related

  2023-11-23

  

  Aurora-A overexpression is also related to the activation of NF-κB, a potent anti-apoptotic effector that may play a role in preventing apoptosis in cancer Evans Blue tetrasodium salt [18]. These data show that we are still at the beginning of unraveling the complex mechanism by which these gene p

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