• The first suggestions that the cleaved intracellular domain

  2023-11-27

  

  The first suggestions that the cleaved intracellular domain of APP, AICD, might transit to the nucleus and hence selectively regulate gene transcription arose from analogies with the Notch receptor signalling system where similar intra-membrane proteolysis occurs [84], [85] and it was later confirme

• br Diabetes and obesity fit or

  2023-11-27

  

  Diabetes and obesity: fit or fat; sugar or not: the autophagic verdict Type 2 diabetes and obesity are among the most emerging health problems worldwide. The factors that are responsible for the establishment of diabetes include decreased pilocarpine hydrochloride mg production, rise in adiposit

• br Material and methods br Results

  2023-11-24

  

  Material and methods Results Discussion Asparagine, arginine, leucine, methionine, and glutamine are the essential KU-0060648 for cancer cells and intensively investigated for the development of selective targeted therapeutics. Among them, asparagine depleting bacterial enzyme asparaginase

• Since the beginning of s more than papers

  2023-11-24

  

  Since the beginning of 1990s, more than 17,000 papers about physiological relevance of antioxidants have been published according to data from web of science. Based on the available literature, it seems that assessing the antioxidant potential of food by means of in vitro assays or solely epidemiol

• Since primitive societies plants herbs

  2023-11-24

  

  Since primitive societies, plants, herbs and seeds, rich in phytochemicals, were used due to their benefits in human health. These molecules were shown to present a diverse array of action mechanisms, including antioxidant activity, enzyme stimulation, hormones mimicking and by interfering with DNA

• br Androgen interference with the action of arachidonic

  2023-11-24

  

  Androgen interference with the action of arachidonic GSK1016790A metabolites’ actions; the other side of the coin Arachidonic acid, being a polyunsaturated fatty acid present in the phospholipids of the membrane of cells, is highly abundant within the organism. It is mainly involved in cellular

• br Conclusions br Conflict of interest br

  2023-11-24

  

  Conclusions Conflict of interest Introduction Plants often encounter a series of abiotic stresses during the growth process, including high salinity, extreme temperatures and drought (Knight and Knight, 2001). Plants can adapt through ionic and osmotic homeostasis or osmotic adjustment, con

• br Colabeling evidence for ACh

  2023-11-24

  

  Colabeling evidence for ACh and GABA cotransmission Though functional demonstrations of ACh/GABA cotransmission remain largely limited to the retina and our recent analyses of cortex (Lee et al., 2010, Saunders et al., 2015a, Saunders et al., 2015b), evidence suggestive of ACh/GABA cotransmission

• Aurora A overexpression is also related

  2023-11-23

  

  Aurora-A overexpression is also related to the activation of NF-κB, a potent anti-apoptotic effector that may play a role in preventing apoptosis in cancer Evans Blue tetrasodium salt [18]. These data show that we are still at the beginning of unraveling the complex mechanism by which these gene p

• Inactivation of the proton pump

  2023-11-23

  

  Inactivation of the proton pump comes with luminal alkalinization of the targeted vesicles such as lysosomes (Fig. 2b). Lysosome pH can also be raised stoichiometrically by addition of a membrane-permeable weak Cy5 EGFP mRNA such as methylamine or chloroquine which accumulates in its protonated, non

• br Results br Discussion Both ATM

  2023-11-23

  

  Results Discussion Both ATM and ATR are key regulators of the cellular response to DSBs, yet how exactly they function in concert is not well understood. Recent studies revealed that ATM is required for the resection of DSBs (Jazayeri et al., 2006, Myers and Cortez, 2006), a process necessary

• Somatostatin analogs also bind to somatostatin

  2023-11-23

  

  Somatostatin analogs also bind to somatostatin receptors. It has been reported that octreotide has a high affinity for hSSTR2, moderate affinity for hSSTR3 and hSSTR5, and does not bind to hSSTR1 or hSSTR4 (Ben-Shlomo and Melmed 2008). Compared to octreotide, pasireotide displays 40-, 30-, and 5-fo

• br Results br Discussion Control

  2023-11-23

  

  Results Discussion Control of chronic inflammation is important in several inflammatory conditions like asthma, rheumatoid arthritis and fibrosis in lung diseases. The regulatory pathways that control chronic inflammation are complex and multi-factorial. Over expression of inflammatory mediato

• The loss of synaptic proteins such

  2023-11-23

  

  The loss of synaptic proteins such as synaptophysin from the Phusion high-fidelity DNA polymerase is indicative of synapse degeneration and provided a good correlate of the degree of dementia in AD [12], [13], [14]. Consequently, the loss of synaptic proteins from cultured primary neurons incubated

• br Introduction Hepatocellular carcinoma HCC is

  2023-11-23

  

  Introduction Hepatocellular carcinoma (HCC) is the third-leading cause of cancer-related death worldwide and accounts for 70–85% of all liver cancer diagnoses [1]. In East and South-East Asia, the occurrence of HCC and the related number of fatalities have gradually increased in recent decades [2

16354 records 245/1091 page Previous Next First page 上5页 241242243244245 下5页 Last page