• Tirofiban Initially we carried out gap FRAP experiments usin

  2021-10-19

  

  Initially, we carried out gap-FRAP experiments using the two-photon configuration of the confocal microscope. A SR101-positive astrocyte was targeted and a 5 × 5 μm square area was exposed to a laser illumination (5 flashes of 5 s each during 25 s). This procedure resulted in a bleaching of this ast

• Consistently with the above discoveries it has

  2021-10-19

  

  Consistently with the above discoveries, it has been also shown that in cardiomyocytes with shRNA-down-regulated FBP2, mitochondria are more susceptible to depolarisation (Gizak et al., 2012a) and H2O2-induced oxidative stress (Wiśniewski et al., 2017). In NMS-1286937 receptor overexpressing FBP2 (c

• Disodium (R)-2-Hydroxyglutarate The above inferences conclud

  2021-10-19

  

  The above inferences concluded that histidine is enhancing the overall stability and rigidity of the protein which further might be restraining the protein during the transition from inactive to active state and vice-versa present in the SANT domain. Since the SANT domain binds with histone via elec

• EPZ031686 br Results br Discussion A key step in the

  2021-10-19

  

  Results Discussion A key step in the regulation of gene EPZ031686 is the methylation on H3K4, which is added by the multi-component MLL/COMPASS-like histone methyltransferases. Many studies have shown the requirement of shared core subunits for optimal methylation activity of catalytic SET pro

• 11-dUTP Acknowledgements br Introduction Histamine mediates

  2021-10-19

  

  Acknowledgements Introduction Histamine mediates various physiological functions and pathological actions through its interactions with histamine receptors that belong to the superfamily of seven transmembrane G-protein-coupled receptors (GPCRs) (Haas et al., 2008). Four histamine receptor subty

• In the adult normal spinal cord

  2021-10-19

  

  In the adult normal spinal cord, the resident cells mainly include neurons, astrocytes, oligodendroglia and microglia (Lecca et al., 2012, Miyagi et al., 2012). After SCI, the lesion microenvironment is complex, which includes the functional changes of CNS resident cells and the infiltration of leuk

• Similar to Rac Cdc and RhoA expression of Rnd is

  2021-10-19

  

  Similar to Rac1, Cdc42, and RhoA, expression of Rnd3 is also increased under hypoxic conditions, involving Hif1α mediated transcriptional activity. Here, downregulation of Rnd3 abolishes hypoxia-induced cell migration via a mechanism involving the chemokine receptor C-X-C motif chemokine receptor 4

• br Several reports have shown

  2021-10-19

  

  Several reports have shown an anti-proliferative effect of type I IFNs on CD4+ T Anisodamine activated in vitro either upon anti-CD3 antibody treatment [28,29] or upon cognate antigen stimulation [29]. However, the in vivo setting is a lot more complex, since the final outcome is the net effect o

• To further implicate the role of EAAT

  2021-10-19

  

  To further implicate the role of EAAT3 in morphine-induced place preference, the effects of morphine on EAAT3 Rizatriptan Benzoate was determined. Interestingly, morphine increased EAAT3 protein expression in the plasma membrane of mPFC, nucleus accumbens and VTA but not in the hippocampus of wild-

• The developed method was used to quantify RBC membrane trans

  2021-10-19

  

  The developed method was used to quantify RBC membrane transport of the anomers of three monofluorinated analogs of glucose in a modified medium designed to provide stable metabolic properties of the cells over the lifetime of the experiment. This allowed us to evaluate the specific interaction (spe

• Fmoc-Trp-OH Bacterial GluRS comes in two flavors discriminat

  2021-10-19

  

  Bacterial GluRS comes in two flavors, discriminatory GluRS (D-GluRS) and non-discriminatory GluRS (ND-GluRS). While D-GluRS exclusively catalyses the transfer of Glu to tRNAGlu, the ND-GluRS can also glutamylate tRNAGln forming Glu-tRNAGln. The misacylated product is then transformed to Gln-tRNAGln

• Introduction Erythrocyte membrane proteins or

  2021-10-19

  

  Introduction Erythrocyte membrane proteins or their orthologs are found in almost all SLIGKV-NH2 mg of the body [1,2]. Because of this compositional similarity and the erythrocyte membrane's accessibility, the red blood cell membrane (RBCM) has served as a crude model for mammalian plasma membrane

• br Gap junctions hemichannels and connexins Molecular charac

  2021-10-18

  

  Gap junctions, hemichannels and connexins: Molecular characteristics and function Cell-to-cell communication is of extreme importance in tissue homeostasis, which is maintained by transmission of regulatory signals (Fig. 1). Intercellular communication via gap junctions (GJs) represents one of th

• Somatostatin analogues are among the first peptide based

  2021-10-18

  

  Somatostatin analogues are among the first peptide-based drugs used in cancer imaging and therapy (for review see Reubi, 2003). Treatment of tumors by the use of peptide analogues labeled with cytotoxic agents acting via specific receptors is also under investigation for neuropeptide Y (Koglin and B

• The primary or in transit site

  2021-10-18

  

  The primary or in-transit site of metastasis for many cancers, including melanoma, are nearby sentinel lymph nodes (LNs) [6]. As such, sentinel LN biopsy is a common procedure to diagnose and stage melanoma progression [7,8]. Sentinel LNs are often the primary site of metastasis due to tumor cell-st

16367 records 584/1092 page Previous Next First page 上5页 581582583584585 下5页 Last page